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Prolonged glucocorticoid exposure reduces hippocampal neuron number:implications for aging. The review included randomized stud-ies of infants either treated early with NCPAPor extubated to NCPAP

The review included randomized stud-ies of infants either treated early with NCPAPor extubated to NCPAP.

The reported rates of periprosthetic ankle joint infec-tion (PAJI) range from 2 to 8.6% [3–10]. Various clinical stud-ies have shown benefit from different groups ofantihypertensive agents in the primary preventionand secondary prevention; however, calcium chan-nel antagonists appear to be particularly useful forlong-term blood pressure management in strokeprevention and a target systolic blood pressurebelow 130 mmHg is reasonable for most patients(5,9)

Various clinical stud-ies have shown benefit from different groups ofantihypertensive agents in the primary preventionand secondary prevention; however, calcium chan-nel antagonists appear to be particularly useful forlong-term blood pressure management in strokeprevention and a target systolic blood pressurebelow 130 mmHg is reasonable for most patients(5,9). Within this context, the DSM-5recognizes the in?uence of “neural substrates, family traits, genetic riskfactors, speci?c environmental risk factors, biomarkers, temperamentalantecedents, abnormalities of emotional or cognitive processing, symp-tom similarity, course of illness, high comorbidity and shared treatmentresponse” (DSM-5, APA, 2013, p. (1989) Major bleeding in outpa-tients treated with warfarin: incidence and prediction by factorsknown at the start of outpatient therapy. However, none of these studieswas a randomized placebo-controlled trial

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It iscurrently believed that there is a continuum of normalcognitive aging, MCI, and dementia, and although eachhas a characteristic clinical phenotype, it can be diffi cultto distinguish normal aging from MCI and to distin-guish MCI from dementia, especially at their intersec-tions.

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